皮肤细胞新闻

皮肤细胞新闻is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Quoin Pharmaceuticals Announces FDA Clearance of IND for its Lead Asset, QRX003, for Netherton Syndrome

4月25日，2022年4月

[Quoin Pharmaceuticals, Inc.] Quoin Pharmaceuticals Ltd. announced that it has received FDA clearance to initiate clinical testing for its Investigational New Drug application for QRX003, the Company’s investigational product for Netherton Syndrome.

Sol-Gel Technologies and Galderma Announce FDA Approval of EPSOLAY®

4月25日，2022年4月

[Sol-Gel Technologies Ltd.] Sol-Gel Technologies, Ltd. announced the FDA approval of its drug product, EPSOLAY®, a proprietary cream formulation of benzoyl peroxide, 5%, for the treatment of inflammatory lesions of rosacea in adults.

Sphingolipids Control Dermal Fibroblast Heterogeneity

4月25日，2022年4月

[Science] Researchers found that the cell-to-cell variations of specific lipid metabolic pathways contribute to the establishment of cell states involved in the organization of skin architecture.

Weight-Bearing Activity Impairs Nuclear Membrane and Genome Integrity via YAP Activation in Plantar Melanoma

4月25日，2022年4月

[Nature Communications] Scientists showed that the nuclear and micronuclear membranes of melanoma cells were frequently ruptured by macroscopic mechanical stress on the plantar surface due to weight-bearing activities.

Effect of the Most Common Wound Antiseptics on Human Skin Fibroblasts

4月25日，2022年4月

[Clinical and Experimental Dermatology] Scientists determined the effects of hexetidine, povidone-iodine, undecylenamidopropyl-betaine/polyhexanide, chlorhexidine, disodium eosin, and hydrogen peroxide, on human skin fibroblasts.

Impact of Portuguese Propolis on Keratinocyte Proliferation, Migration and ROS Protection: Significance for Applications in Skin Products

4月25日，2022年4月

[International Journal of Cosmetic Science] Researchers probed the action of Portuguese propolis extracts on skin cells, provided mechanistic insights into its mode of action and preliminarily assesed its applicability as a skin repair ingredient.

Monitoring Wound Healing with Topically Applied Optical NanoFlare mRNA Nanosensors

4月25日，2022年4月

[Advanced Science] Investigators reported the development and utilization of mRNA nanosensors that were topically applied on cutaneous wounds to reveal the healing status through targeted and semi-quantitative examination of the mRNA biomarkers in skin cells.

2-Methoxyestradiol Inhibits Melanoma Cell Growth by Activating Adaptive Immunity

4月25日，2022年4月

[Immunopharmacology and Immunotoxicology] The authors found that 2-methoxyestradiol significantly affected the proliferation, migration, apoptosis, and cell cycle of melanoma体外。

CXCL12 Inhibits Hair Growth through CXCR4

4月25日，2022年4月

[Biomedicine & Pharmacotherapy] Researchers investigated the expression of CXCL12 and its receptor, CXCR4, in the vicinity of hair follicles and their effect on hair growth.

Luteolin Binds Src, Promotes STAT3 Protein Ubiquitination and Exerts Anti-Melanoma Effects in Cell and Mouse Models

4月25日，2022年4月

[Biochemical Pharmacology] Ten cell lines and two mouse models were used for assessing the体外和体内anti-melanoma effects of luteolin.

CB-RAF600E-1通过双重抑制RAS/RAF/MEK/ERK和PI3K/AKT信号通路，通过双重抑制Vemurafenib抗性和非耐药性黑色素瘤细胞发挥功效

4月25日，2022年4月

[Saudi Journal of Biological Sciences] Reversal of cancer symptoms in melanoma associated with vemurafenib resistance was driven by reactivation of MAPK and PI3K/Akt signaling pathways.

Ectopic Odorant Receptors Responding to Flavor Compounds in Skin Health and Disease: Current Insights and Future Perspectives

4月25日，2022年4月

[Critical Reviews in Food Science and Nutrition] The authors review and discuss latest discoveries related to the skin odorant receptors (ORs) activated by flavor compounds, their impacts on skin health and disease, odorant ligands interacting with ORs exerting specific biological effects, and the mechanisms involved.

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As the largest organ in the human body, the skin is implicated in a wide range of health conditions.皮肤细胞新闻is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.