携带HSA-miRNA-128-3P的人脐带间充质干细胞衍生的外来通过抑制半乳糖蛋白-3抑制胰腺导管细胞癌

研究人员研究了外来物质从携带HSA-miRNA-128-3P的人脐带间充质干细胞上提取的外来体在胰腺癌细胞上。爱游戏app下载视频
[Clinical and Translational Oncology]
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IMB5036 Inhibits Human Pancreatic Cancer Growth Primarily through Activating Necroptosis

MLKL inhibitor NSA attenuated the killing effect of IMB5036 on pancreatic cancer cells. IMB5036 stimulated translocation of MLKL and p-MLKL from cytoplasm to cell membrane.
[Basic & Clinical Pharmacology & Toxicology]
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Glycosylation of MUC6 by α1,4-Linked N-acetylglucosamine Enhances Suppression of Pancreatic Cancer Malignancy

Investigators ectopically expressed α1,4-N-acetylglucosaminyltransferase (α4GnT), the α1,4-linked N-acetylglucosamine biosynthetic enzyme, together with MUC6 in the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, neither of which expressed α4GnT and MUC6.
[癌症科学]
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MCT4 as a Potential Therapeutic Target to Augment Gemcitabine Chemosensitivity in Resected Pancreatic Cancer

Investigators identified the prognostic significance and therapeutic options of metabolic subtypes of resectable pancreatic cancer.
[Cellular Oncology]
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HIG1 Domain Family Member 1A Disrupts Proliferation, Migration and Invasion of Colon Adenocarcinoma Cells

HIGD-1A促进胰腺癌细胞的增殖和胰腺癌的生长;然而,没有针对结肠直肠癌(CRC)的类似观察结果。研究人员核实了HIGD-1A在结肠直肠癌中的作用。
[Bioengineered]
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MicroRNA-190b Expression Predicts a Good Prognosis and Attenuates the Malignant Progression of Pancreatic Cancer by Targeting MEF2C and TCF4

Scientists examined the expression of miR‑190b in pancreatic cancer cell lines and tissues and evaluated its effects on cancer progression.
[肿瘤学报告]
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ACY-241, an HDAC6 Inhibitor, Overcomes Erlotinib Resistance in Human Pancreatic Cancer Cells by Inducing Autophagy

Researchers evaluated the anticancer effect of ACY-241, an HDAC6-selective inhibitor, on erlotinib-resistant pancreatic cancer cells that overexpressed HDAC6.
[药物研究档案]
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ARL4C通过调节肿瘤 - 基质相互作用来促进胰腺癌的生长和耐药性

Researchers examined the proliferation and drug resistance effect of ADP-ribosylation factor like-4c (Arl4c) on pancreatic cancer cells. They explored the contribution of Arl4c high expression in pancreatic stellate cell activation.
[荒谬]
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4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine Induces Immunogenic Cell Death in Colon and Pancreatic Carcinoma Models as a Single Agent

RNA sequencing experiments were conducted on PANC-1 human pancreatic cancer cells treated with Docosahexaenoyl difluorodeoxycytidine (DHA–dFdC), dFdC, or vehicle control体外
[Cancer Chemotherapy and Pharmacology]
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Development and Evaluation of Icariin-Loaded PLGA-PEG Nanoparticles for Potentiation the Proapoptotic Activity in Pancreatic Cancer Cells

Therapeutic efficacy of antineoplastic agents possessing a selective target to the nucleus of the cancer cells could be enhanced through novel formulation approaches. Scientists showed that optimized formula enhanced cytotoxicity and apoptotic potential, compared with icariin (ICA)-raw, against pancreatic cancer cell lines.
[Aaps Pharmscitech]
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MK8722,AMPK活化剂,抑制人类胰腺癌细胞中的癌细胞增殖,侵袭和迁移

MK8722 is a potent and systemic pan-AMPK activator. It is an effective, direct, allosteric activator of AMPK complex in many mammals. Scientists investigated the anti-pancreatic cancer cells effects of MK8722 on two different human pancreatic cancer cell lines.
[Biomedicine和药物治疗]
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